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Two new microbiome studies bracket the human lifespan, hinting that the bacteria in our intestines track with both extreme longevity and cognitive decline. The signals are early, but intriguing.
Women rack up more frailty as they age, yet keep outliving the men around them. New centenarian data hints that the answer is hiding in their inflammation.
A new wave of 2025 research points to specific molecular levers that distinguish the brains of healthy agers from the rest — and hints at what the rest of us might one day borrow.
A new whole-exome analysis of 1,245 long-lived Germans finds rare variants clustering in the mTOR pathway — the same one rapamycin targets — offering rare human evidence for a mechanism mostly studied in animals.
Two 2025 studies converge on measurable biological signatures that set centenarians—and long-lived mammals—apart. The evidence is intriguing, the mechanisms partial, the hype unwarranted.