Longevity
The Fatty Acid Signature of Healthy Aging to 80
A 15,000-person cohort sharpens which fats in your bloodstream travel with healthspan — not just the years, but the years lived free of major disease.
healthspan
Longevity
Sirolimus for Longevity: The First Formal Reckoning on Off-Label Anti-Aging Use
A transplant drug has become the longevity movement's favorite gamble. Now clinical pharmacologists are saying, in plain language, that the evidence isn't there yet.
Protocols
The Frailty Playbook: How Nutrition and Training Can Rewind Age-Related Decline
A 2025 review in Advances in Experimental Medicine and Biology argues frailty — unlike aging itself — is reversible. The two levers: personalized nutrition and structured exercise.
Longevity
The Longevity Inheritance: What the Brains of Centenarians' Children Reveal
A new imaging study of adults whose parents lived exceptionally long lives finds a distinctive gray-matter signature — a structural hint that 'good genes' may be visible on a scan.
Longevity
Can Physical Resilience Outrun Your Genes? A Swedish Cohort Says Maybe
In more than 3,000 older adults, a clever measure of bounce-back capacity blunted the mortality penalty of inheriting genes for a shorter life — a moderate but provocative signal for the fitness-forward crowd.
Longevity
What a Century-Old Cave Salamander Might Teach Us About Slow Aging
Researchers have mapped the first full transcriptome of the olm, an amphibian that lives more than 100 years in the dark. The early findings hint at how some animals stretch a lifespan — and why human biology might one day borrow the trick.
Longevity
Epigenetic Clocks Hold Up Across Borders — and Your Habits Still Move the Needle
A new three-country study finds that the biological-age tests longevity fans love track smoking, heavy drinking, and BMI with surprising consistency. The catch? They only budge if your behavior does.
Longevity
Senotherapeutics 2.0: A Reishi Molecule, Rapamycin's Shadow, and the AI Hunt for Anti-Aging Drugs
A reishi-derived compound matched rapamycin in worms and rejuvenated aged mice. A parallel review maps how machine learning is industrializing the search for the next generation of senolytics.
Longevity
Nocturia After 60: A Quiet Symptom That May Predict Frailty
New Berlin Aging Study II data suggest that waking at night to urinate isn't merely a nuisance — it may be an early, observable signal of functional decline in older adults.
Longevity
Are Life Expectancy Gains Finally Slowing? What New Cohort Forecasts Mean for Your Healthspan
A sweeping new analysis across 23 high-income countries says the steady climb in lifespan is losing steam. Here's what that actually means for the choices you make now.