Felix Mercer
Longevity Correspondent
Longevity maximalists tracking the cutting edge of lifespan science
Felix Mercer is PinnacleLife's longevity correspondent, tracking the frontier of lifespan science — senescence, NAD, rapamycin, biological-age testing and the people pushing it forward. Optimistic about the future, ruthless about the evidence.
Latest articles
Move Your Way: Why Leisure-Time Activity May Slow Biological Aging More Than Work or Commuting
A new analysis of more than 18,000 adults parses exercise by domain—and finds the clock-slowing benefits aren't distributed evenly. Sweat on your own time appears to matter more than sweat on the job.
Brain-Computer Interfaces Grow Up: Why Individualization Is the Next Frontier
The lab demos are dazzling, but a new review argues the real unlock for BCIs is designing around the person — their development, their aging brain, their life.
The Liver as the Body's Aging Switchboard
A new synthesis recasts hepatic mitochondria as a systemic signaling hub — broadcasting blood-borne cues that remodel distant tissues and hinting at a therapeutic class beyond senolytics.
What Centenarians' Gut Bugs — and a Nursing Home's — May Be Telling Us About Aging
Two new microbiome studies bracket the human lifespan, hinting that the bacteria in our intestines track with both extreme longevity and cognitive decline. The signals are early, but intriguing.
Dementia Before 65: New Cohort Data Shows Early-Onset Risk Looks Different
A harmonised analysis of five major UK and US cohorts finds that the midlife risk factors for early-onset dementia don't always track the familiar late-onset picture — a moderate but consequential signal for how we screen.
The Sarcopenia–Atherosclerosis Loop: Why Muscle Loss and Vascular Aging Feed Each Other
A new mechanistic review argues that after 50, the cardiovascular system and the skeletal muscle system age as one. Protecting muscle, in other words, may be vascular medicine in disguise.
UV Rewrites Your Skin's Genome: A Transcriptomic Atlas of Photoaging
A new multi-age comparative study reads the molecular fingerprints UV leaves on skin — and quietly makes sunscreen the most evidence-backed anti-aging tool we have.
Senolytics Go Mainstream: Killing Zombie Cells to Save Aging Bones
Two 2025 studies converge on a striking thesis — that clearing senescent cells, with drugs or even intermittent pressure, may halt age-related bone loss in mice. Here's what the preclinical signal actually says.
The Sirtuin–Senescence Axis: Mapping the Molecular Drivers of Aging
Three converging 2025 reviews sketch an integrated picture of why tissues deteriorate—and where senolytics, NAD+ modulators, and lysosome-restoring therapies might one day intervene.
Biological Age, Decoded: Blood-Based Clocks and the Hunt for Geroprotectors
A seven-marker aging clock built on nearly 60,000 blood samples and machine-learning screens for natural geroprotectors hint at a clinic-ready future for longevity medicine — with caveats.
Can Physical Resilience Outrun Your Genes? A Swedish Cohort Says Maybe
In more than 3,000 older adults, a clever measure of bounce-back capacity blunted the mortality penalty of inheriting genes for a shorter life — a moderate but provocative signal for the fitness-forward crowd.
Blood Proteins as an Aging Clock: The Proteomic Panel Coming for Methylation
A new systematic review pools 17 plasma proteomics datasets into a shortlist of candidate proteins — the scaffolding for a next-generation aging clock that may one day rival DNA methylation.